Originating from the homonymous region of Sichuan, in southwestern China, Sichuan pepper is a delicacy widely used in traditional Chinese medicine. For centuries, it has been used to relieve symptoms such as itching and toothache, which earned it the nickname “Toothache Tree” or, in the literal translation, “Toothache Tree”.

This spice is notable for its unique ability to cause a sensation of numbness in the mouth, a characteristic attributed to the presence of hydroxyalkamides in its composition, especially a diastereomeric unsaturated amide known as α-hydroxy-sanshool.4 The sensations of numbness and tingling caused by α-hydroxy-sanshool can be interpreted as forms of transient paresthesia, which, in turn, can exert an inhibitory effect on the neuromuscular junction

This inhibition mechanism in the transmission of nerve signals at the neuromuscular junction is the result of the temporary effect that compounds such as α-hydroxy-sanshool exert on the sodium and potassium channels of nerve cells. Such interaction can contribute to muscle relaxation, considering that the muscle contraction process begins from a nerve impulse, which, in this case, is being inhibited.

In this way, NV AgeFreeze contributes to skin rejuvenation by promoting muscle relaxation, by inhibiting the transmission of signals between nerves and muscles in the dermal layer. This effect not only smoothes fine lines and wrinkles, but also improves the overall texture of the skin, offering an innovative approach to skin care based on active ingredients derived from natural sources.